Quinoxalinedione deprotonation is important for glutamate receptor binding
نویسندگان
چکیده
منابع مشابه
Identification of amino acids in the glutamate receptor, GluR3, important for antibody-binding and receptor-specific activation.
We reported (Twyman, R. E., Gahring, L. C., Speiss, J., and Rogers, S. W. (1995) Neuron 14, 755-762) that antibodies to a subregion of the glutamate receptor (GluR) subunit GluR3 termed GluR3B (amino acids 372-395), act as highly specific GluR agonists. In this study we produced additional rabbit anti-GluR3B-specific antibodies, ranked them according to their ability to function as GluR agonist...
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متن کاملQuantitative physiological characterization of a quinoxalinedione non-NMDA receptor antagonist.
The effects of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, or FG 9065) on excitatory amino acid responses in cultured neurons from rat hippocampus were studied using tight-seal whole-cell recording techniques. CNQX reduced the magnitude of peak inward currents produced by exogenously applied kainate, quisqualate, and N-methyl-D-aspartate (NMDA) with Ki's of 2.5, 3.5, and 96 microM, respectively...
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ژورنال
عنوان ژورنال: Biological Chemistry
سال: 2019
ISSN: 1437-4315,1431-6730
DOI: 10.1515/hsz-2018-0464